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| Second Basemen Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Francis Gaston | 362 | 2102 | 1952-1955 | |
| 2. | Claude Ring | 346 | 1843 | 1952-1955 | |
| 3. | Gregory Kuhn | 323 | 1775 | 1952-1955 | |
| 4. | Edward Shiflett | 321 | 1938 | 1952-1955 | |
| 5. | Brian Underwood | 317 | 2216 | 1952-1955 | |
| 6. | Toby Paschke | 315 | 2201 | 1952-1955 | |
| 7. | Dudley Langworthy | 297 | 2247 | 1952-1955 | |
| Joseph Stovall | 297 | 1551 | 1952-1954 | ||
| 9. | Sergio Rondon | 288 | 2341 | 1952-1955 | |
| 10. | James Carrillo | 272 | 2102 | 1952-1955 | |
| 11. | Craig Wright | 269 | 1307 | 1952-1955 | |
| 12. | Walter Salgado | 258 | 2260 | 1952-1955 | |
| 13. | Andrea Bader | 257 | 1617 | 1952-1955 | |
| 14. | Joe Whelan | 255 | 2407 | 1952-1955 | |
| 15. | Rupert Witty | 243 | 1262 | 1952-1955 | |
| 16. | Russ Witham | 232 | 1869 | 1952-1955 | |
| 17. | David Burner | 223 | 1288 | 1953-1955 | |
| 18. | Felix Bronner | 208 | 2067 | 1952-1955 | |
| 19. | John Rooks | 201 | 971 | 1952-1955 | |
| 20. | Jason Seger | 168 | 1268 | 1953-1955 | |
| 21. | Ryan Good | 163 | 2231 | 1952-1955 | |
| 22. | Frank Hardin | 161 | 732 | 1952-1953 | |
| 23. | Michael Nagy | 160 | 1133 | 1952-1955 | |
| 24. | Michael Mitchell | 155 | 1229 | 1952-1955 | |
| 25. | David Mefford | 141 | 718 | 1952-1955 | |
| 26. | Kenneth Curry | 124 | 1026 | 1952-1955 | |
| 27. | Casimiro Dominguez | 121 | 619 | 1953-1955 | |
| 28. | Joseph Smith | 120 | 697 | 1952-1955 | |
| 29. | Eric Peck | 105 | 414 | 1952-1955 | |
| 30. | Robert George | 91 | 571 | 1952-1955 | |
| 31. | William Pettitt | 89 | 858 | 1952-1955 | |
| 32. | Ramon Dearmas | 88 | 763 | 1953-1955 | |
| 33. | Jarod Reed | 74 | 530 | 1952-1955 | |
| 34. | Bill Hollins | 69 | 341 | 1955-1955 | |
| 35. | Rickey Hunziker | 68 | 400 | 1952-1953 | |
| 36. | Adam Washington | 62 | 288 | 1952-1955 | |
| 37. | Jonathan Irick | 55 | 464 | 1955-1955 | |
| 38. | Scott Ewing | 41 | 301 | 1952-1955 | |
| 39. | William Park | 39 | 180 | 1952-1953 | |
| 40. | Brian Scudder | 38 | 153 | 1953-1953 | |
| 41. | John Reyes | 36 | 247 | 1955-1955 | |
| 42. | William Waguespack | 28 | 149 | 1952-1955 | |
| 43. | Edwin Carter | 26 | 130 | 1953-1954 | |
| 44. | Jaime Gall | 25 | 163 | 1952-1955 | |
| 45. | Antonio Zubiri | 23 | 189 | 1953-1954 | |
| 46. | Odis Marcial | 17 | 106 | 1954-1954 | |
| 47. | Bernal Morales | 7 | 51 | 1953-1955 | |
| Bruce Pounders | 7 | 14 | 1954-1954 | ||
| John Morvant | 7 | 43 | 1952-1952 | ||
| 50. | Harry Jones | 5 | 36 | 1953-1955 | |
| Donald Steve | 5 | 15 | 1955-1955 | ||
| 52. | Timothy Harrison | 3 | 21 | 1953-1954 | |
| 53. | Kristofer Hallam | 2 | 10 | 1955-1955 | |
| Lawrence Cuddy | 2 | 6 | 1955-1955 | ||
| 55. | Robert Lococo | 1 | 11 | 1955-1955 | |
| Vincent Chapel | 1 | 12 | 1952-1952 |
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