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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Ezequiel Sánchez# | 35 | 2015 | |
| 2 | John Soriano# | 25 | 2015 | |
| 3 | Pedro Ortíz# | 20 | 2015 | |
| 4 | Eric Doll# | 18 | 2015 | |
| 5 | Ryan Olson# | 15 | 2015 | |
| 5 | Vicente Velásquez# | 15 | 2015 | |
| 7 | David Sims# | 13 | 2015 | |
| 7 | Jesús Gonzáles# | 13 | 2015 | |
| 9 | José González# | 12 | 2015 | |
| 10 | José Raimundo# | 11 | 2015 | |
| 10 | Adam Anderson# | 11 | 2015 | |
| 12 | Ricardo Castellanos# | 10 | 2015 | |
| 13 | Dan Huff# | 9 | 2015 | |
| 13 | Brian McBride# | 9 | 2015 | |
| 15 | Brady Simpson# | 8 | 2015 | |
| 16 | Ken Jackson# | 7 | 2015 | |
| 16 | Matt Owen# | 7 | 2015 | |
| 16 | Ernesto Marés# | 7 | 2015 | |
| 19 | Vicente Pacheco# | 4 | 2015 | |
| 19 | Ramón López# | 4 | 2015 |
