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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Jason Seger | 397 | 1953-1969 | |
| 2 | Roberto Pacheco | 309 | 1999-2013 | |
| 3 | Kenny Harper | 295 | 1964-1976 | |
| 4 | Nathan Simon# | 274 | 2001-2015 | |
| 5 | Larry Stone* | 270 | 1963-1985 | |
| 6 | Trevor Seals* | 263 | 1969-1991 | |
| 7 | Roberto Méndez | 250 | 1979-1995 | |
| 8 | Roy Méndez | 245 | 1987-2001 | |
| 9 | Miguel Reséndez# | 243 | 2007-2015 | |
| 10 | Ronald Whitson | 226 | 1958-1971 | |
| 11 | Germán Palmeiro | 223 | 1978-1991 | |
| 12 | Bryan Cooper | 213 | 1979-1994 | |
| 12 | Bobby Williamson | 213 | 1962-1977 | |
| 14 | Luis Maldonado# | 206 | 2002-2015 | |
| 15 | Héctor López | 202 | 1986-1996 | |
| 16 | Chuck Hurley | 194 | 1975-1987 | |
| 17 | Lawrence Cuddy | 192 | 1955-1968 | |
| 18 | Il-young Pang | 190 | 1997-2006 | |
| 19 | Jeffrey Souza | 189 | 2002-2011 | |
| 20 | Christopher Davis | 181 | 1960-1974 | |
| 21 | Robert Lococo | 180 | 1955-1971 | |
| 22 | Lionel Chavez | 174 | 1959-1966 | |
| 23 | Tony Vásquez | 169 | 1965-1974 | |
| 24 | Robert Edmonds | 166 | 1958-1975 | |
| 25 | Michael Nelson | 164 | 1978-1993 | |
| 26 | Kazuyoshi Kichida# | 157 | 2011-2015 | |
| 27 | Pedro García | 156 | 1999-2014 | |
| 28 | Reynaldo González | 144 | 1977-1991 | |
| 29 | Miguel Angel Longoria | 142 | 1981-1995 | |
| 30 | Jeffery Palmer | 139 | 1980-1988 | |
| 31 | Andrew Hunter | 137 | 1965-1979 | |
| 32 | Jonathan Bramlett | 136 | 1960-1968 | |
| 32 | Albert Sherman | 136 | 1956-1967 | |
| 34 | Steve Martin | 135 | 2000-2011 | |
| 35 | Freddie Corbett | 134 | 1962-1974 | |
| 36 | Enrique Fabián | 133 | 1963-1979 | |
| 36 | Floyd Hayes | 133 | 1985-1997 | |
| 38 | Jesse Davis | 132 | 1988-1995 | |
| 39 | Ed Jordan | 130 | 1980-1998 | |
| 40 | Raleigh Taylor | 129 | 1964-1977 | |
| 41 | Esteban Nieves | 127 | 1973-1985 | |
| 42 | John Adams | 125 | 1990-2004 | |
| 43 | Joseph Izquierdo* | 124 | 1956-1976 | |
| 43 | Manny Martínez | 124 | 1967-1976 | |
| 45 | Gustavo Javier | 121 | 1989-2001 | |
| 46 | Chris Valadez# | 120 | 2006-2015 | |
| 47 | José Ortíz | 117 | 1988-1999 | |
| 48 | Lance Islam | 116 | 1958-1976 | |
| 48 | Juan Tovar# | 116 | 2008-2014 | |
| 50 | Millard Brandon* | 115 | 1979-1993 | |
| 50 | António Solíz | 115 | 1961-1968 | |
| 52 | Logan Browning | 113 | 1969-1986 | |
| 53 | Arthur Beard# | 110 | 2004-2015 | |
| 54 | Carl Michael | 109 | 1981-1998 | |
| 55 | Craig MacFadden | 107 | 1966-1982 | |
| 56 | Marcos León | 106 | 1999-2013 | |
| 57 | Stephen Alexander | 105 | 1958-1970 | |
| 58 | Alfonso Rivera | 103 | 1987-1999 | |
| 59 | Brian Frye | 99 | 1967-1977 | |
| 59 | Bill Hicks | 99 | 2004-2015 | |
| 59 | Patrick Nehring | 99 | 1954-1966 | |
| 62 | Mason Griffin# | 98 | 2009-2015 | |
| 62 | Skip Moon | 98 | 1984-1998 | |
| 62 | Alfredo Rosales | 98 | 1987-1998 | |
| 65 | Andrew Woolum | 95 | 1956-1972 | |
| 66 | Tsuneari Nakashima | 94 | 1991-1995 | |
| 67 | Chris Acheson | 91 | 1987-2005 | |
| 67 | Armando Flader | 91 | 1980-1990 | |
| 69 | Oliver Miller | 90 | 1983-1993 | |
| 70 | Bryan Allen | 83 | 1984-1995 | |
| 70 | José Camacho | 83 | 1968-1978 | |
| 70 | Roy Hopkins# | 83 | 2005-2015 | |
| 70 | Jorge Sandoval | 83 | 1972-1986 | |
| 74 | Colby Black | 81 | 1991-1997 | |
| 75 | Alfonso Aguilar | 76 | 2001-2007 | |
| 75 | Mike Shields | 76 | 1984-1994 | |
| 77 | Ron Davis# | 75 | 2006-2015 | |
| 78 | Matthew Sherman | 72 | 1984-1997 | |
| 79 | Jonathan Hudson | 71 | 1980-1992 | |
| 79 | Andrew Ostrander | 71 | 1954-1966 | |
| 79 | Sergio Rondon | 71 | 1952-1965 | |
| 82 | Sammy Curry | 70 | 1987-2000 | |
| 83 | Quiang Ling | 69 | 1968-1982 | |
| 84 | Nick Glenn | 68 | 1988-2000 | |
| 84 | Robinson Gonzáles | 68 | 1997-2007 | |
| 84 | David Hindman | 68 | 1955-1967 | |
| 84 | James Thomas | 68 | 1982-1988 | |
| 88 | Reggie Williamson# | 67 | 2009-2015 | |
| 89 | Dan Church | 66 | 1987-1996 | |
| 89 | Donnie Cote | 66 | 1964-1971 | |
| 91 | Anthony Sutton | 64 | 1978-1987 | |
| 92 | Oliver Árias | 63 | 1974-1986 | |
| 93 | Millard Rush | 62 | 1969-1982 | |
| 94 | Eddy Watts | 61 | 1987-2002 | |
| 95 | Marc Colbert | 60 | 1977-1984 | |
| 95 | Dave Shaffer# | 60 | 2003-2015 | |
| 97 | António Evans | 59 | 1994-2011 | |
| 97 | Luis Martínez | 59 | 1977-1995 | |
| 99 | Wilson Pérez# | 57 | 2012-2015 | |
| 100 | Ken Lamb | 55 | 2001-2012 |
