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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Enrique Ortíz | 2.231 | 2001-2014 | |
| 2 | Terence Washington | 2.299 | 1988-2000 | |
| 3 | António Rodríguez | 2.303 | 1976-1984 | |
| 4 | Bob Hubbard | 2.306 | 2002-2013 | |
| 5 | Donato Gil | 2.334 | 1993-2007 | |
| 6 | Gavin Burns | 2.338 | 1991-1998 | |
| 7 | Arturo Vázquez# | 2.371 | 2002-2014 | |
| 8 | José Gonzáles | 2.396 | 2000-2009 | |
| 9 | Norberto Gómez | 2.408 | 1985-1995 | |
| 10 | Julián Rodríguez | 2.416 | 1999-2011 | |
| 11 | Chad Phillips | 2.421 | 1993-2001 | |
| 12 | Roberto Vázquez | 2.430 | 1989-2002 | |
| 13 | Vinnie Tyson# | 2.455 | 2001-2012 | |
| 14 | Jesús Rocha | 2.459 | 2008-2014 | |
| 15 | Austin Rose | 2.481 | 1997-2005 | |
| 16 | Carlos Rodríguez | 2.516 | 1984-1996 | |
| 17 | Roberto Talamante | 2.518 | 1987-1996 | |
| 18 | Estaçio Cepa | 2.521 | 1997-2010 | |
| 19 | José Alarcon | 2.527 | 1963-1967 | |
| 20 | Román Manuel | 2.534 | 1994-2010 | |
| 21 | Herman Conway | 2.538 | 1957-1969 | |
| 22 | Phil Longchamps# | 2.539 | 2005-2014 | |
| 23 | Rubén Ramírez | 2.542 | 2003-2014 | |
| 24 | Mark Gregg | 2.543 | 1998-2010 | |
| 24 | Keith Kimbell | 2.543 | 1957-1961 | |
| 26 | Brent House# | 2.551 | 2006-2011 | |
| 27 | José Valéncia | 2.563 | 1990-1998 | |
| 27 | Luis Quezada | 2.563 | 1990-2001 | |
| 29 | Orlando Nevárez | 2.567 | 1989-1996 | |
| 30 | Cole Murphy | 2.582 | 1968-1980 | |
| 31 | José Esparza# | 2.589 | 2006-2014 | |
| 32 | Charlie Krumm | 2.590 | 1997-2009 | |
| 33 | Pablo Lugo | 2.609 | 1991-2005 | |
| 34 | Lou Ames | 2.629 | 1993-2006 | |
| 35 | Ronnie Gordon# | 2.632 | 2004-2014 | |
| 36 | Andre Parks# | 2.638 | 2003-2011 | |
| 37 | Edwin Miller# | 2.652 | 2006-2014 | |
| 38 | Howard Watson | 2.659 | 1992-2000 | |
| 39 | Sean Ward | 2.664 | 1967-1975 | |
| 40 | Rupert Spenser | 2.673 | 1957-1964 | |
| 41 | Bennett Owens | 2.683 | 1975-1985 | |
| 42 | Clarence Gallagher | 2.696 | 1981-1998 | |
| 43 | Sean Connolly | 2.698 | 1988-2000 | |
| 44 | Domingo López# | 2.706 | 2002-2013 | |
| 45 | Pedro Morales | 2.708 | 1995-2008 | |
| 46 | Zak Stewart# | 2.717 | 2004-2012 | |
| 47 | Tom Town | 2.720 | 1957-1959 | |
| 48 | Edgar Vásquez# | 2.730 | 2006-2014 | |
| 49 | Nelson Padilla | 2.743 | 1999-2014 | |
| 50 | Alejandro Pérez | 2.744 | 1991-1999 | |
| 51 | Nathaniel Barnes | 2.745 | 1957-1962 | |
| 52 | Roger Patterson | 2.764 | 1993-1999 | |
| 53 | Paul Hollins | 2.765 | 1987-1998 | |
| 54 | Bill Middleton | 2.768 | 1999-2008 | |
| 55 | Jesús Cardenas# | 2.770 | 2005-2014 | |
| 56 | Alberto Cortéz | 2.772 | 1997-2004 | |
| 57 | Pablo Águila | 2.773 | 1992-2004 | |
| 58 | Martin Martínez | 2.775 | 1993-2000 | |
| 59 | Ralph Frank | 2.777 | 1987-1995 | |
| 59 | Juan Moreno | 2.777 | 1995-2002 | |
| 61 | Randy De Jesús | 2.778 | 1993-2005 | |
| 62 | Richard Richard | 2.781 | 1982-1989 | |
| 63 | Bill Taylor | 2.788 | 1993-2001 | |
| 64 | Tad Lindsay# | 2.793 | 2005-2014 | |
| 65 | António Gallardo | 2.796 | 1996-2009 | |
| 66 | Andrew Sullivan | 2.798 | 1987-1999 | |
| 67 | Donald Wright | 2.808 | 1957-1962 | |
| 68 | Ron Williams | 2.809 | 1968-1978 | |
| 69 | Robbie Moore | 2.811 | 1970-1983 | |
| 70 | Brad Brooks | 2.812 | 1999-2009 | |
| 71 | Thomas Chee | 2.821 | 1957-1962 | |
| 72 | Júlio Rocha# | 2.827 | 2001-2014 | |
| 73 | Martín Díaz | 2.831 | 1971-1974 | |
| 73 | António González | 2.831 | 1971-1984 | |
| 75 | Michael Crawford# | 2.834 | 2002-2013 | |
| 76 | Jeff Cook | 2.838 | 1989-2005 | |
| 77 | António Arenas | 2.845 | 1999-2004 | |
| 77 | Edgardo Mendoza | 2.845 | 1992-2004 | |
| 79 | Lee Faught | 2.847 | 1997-2005 | |
| 80 | Jaime Rosado | 2.848 | 1993-2004 | |
| 80 | Kenny Williams | 2.848 | 1980-1986 | |
| 82 | Juan Carlos López | 2.850 | 1991-1996 | |
| 83 | Tony Salinas | 2.855 | 1997-2005 | |
| 84 | Lee Howard# | 2.856 | 2003-2012 | |
| 85 | Timothy Stradford | 2.861 | 1957-1968 | |
| 86 | Howard Tate | 2.862 | 1991-1999 | |
| 87 | Randy Laidlaw | 2.863 | 1988-2000 | |
| 88 | Arthur Stevens | 2.866 | 1977-1981 | |
| 89 | Lorenzo Talamantes# | 2.868 | 1999-2014 | |
| 90 | Albert Garner | 2.873 | 1965-1975 | |
| 91 | Logan Fontenot# | 2.876 | 2008-2013 | |
| 92 | Beppe Erbetto | 2.878 | 1996-2007 | |
| 93 | Felipe Medina | 2.885 | 2001-2011 | |
| 94 | Larry Barber# | 2.887 | 2003-2013 | |
| 95 | Oscar Filbee | 2.893 | 1983-1990 | |
| 96 | Augusto Ramírez | 2.896 | 1989-2003 | |
| 97 | Bob Foster | 2.898 | 1962-1968 | |
| 98 | Valentín Moreno | 2.900 | 1979-1988 | |
| 99 | Garrett Whiting | 2.904 | 1960-1965 | |
| 100 | Pepe Méndez | 2.907 | 1970-1981 |
