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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Tony Domínguez# | 0.916 | 2013 | |
| 2 | Juan Valenzuela# | 1.075 | 2012 | |
| 3 | John Huntingford# | 1.205 | 2001 | |
| 4 | Gabriel Ordóñez# | 1.244 | 2002 | |
| 5 | Reynaldo Javier | 1.268 | 2008 | |
| 6 | Randall Glenn | 1.377 | 2000 | |
| 7 | Jesús Rocha | 1.401 | 2010 | |
| 8 | Harry Christensen | 1.441 | 1994 | |
| 9 | Paul Montgomery# | 1.449 | 2009 | |
| 10 | Zak Stewart# | 1.459 | 2011 | |
| 11 | John Payne | 1.478 | 1995 | |
| 11 | Jaime Rosado | 1.478 | 1997 | |
| 13 | Mal Holt | 1.511 | 2002 | |
| 14 | Danny Southorn | 1.515 | 1990 | |
| 15 | Sean Ward | 1.518 | 1969 | |
| 15 | Justin O'Brien# | 1.518 | 2013 | |
| 17 | Andy Carroll | 1.527 | 1989 | |
| 18 | Michael Melton | 1.533 | 1990 | |
| 19 | Júlio Baca | 1.556 | 1999 | |
| 20 | Jesse Graham | 1.564 | 1977 | |
| 21 | Juan Valenzuela# | 1.574 | 2010 | |
| 22 | Nick Inman | 1.575 | 1994 | |
| 23 | Mark Gregg | 1.596 | 2008 | |
| 23 | Lynn Raht | 1.596 | 1958 | |
| 25 | Rubén Ramírez | 1.607 | 2008 | |
| 26 | Terence Washington | 1.613 | 1997 | |
| 27 | Tom Holz | 1.618 | 1980 | |
| 28 | Kirk Reese | 1.624 | 1992 | |
| 29 | Keagan Hubley# | 1.628 | 2010 | |
| 30 | Salvador Olvera | 1.642 | 1993 | |
| 31 | Marcus Allen | 1.643 | 1968 | |
| 32 | Augusto Luna | 1.653 | 1991 | |
| 33 | Guillermo Bojórquez | 1.671 | 1989 | |
| 34 | Pablo Águila | 1.680 | 1999 | |
| 35 | Joe Evans | 1.688 | 1992 | |
| 35 | Carlos Rodríguez | 1.688 | 1985 | |
| 37 | Cristo Richardson# | 1.701 | 2009 | |
| 38 | Gene Baker# | 1.703 | 2010 | |
| 38 | Charlie Krumm | 1.703 | 2004 | |
| 40 | Enrique Ortíz | 1.709 | 2001 | |
| 41 | Rob White | 1.713 | 1992 | |
| 42 | Nelson Padilla | 1.716 | 2013 | |
| 43 | Jae-bok Im | 1.717 | 1969 | |
| 44 | Gonzalo Mesa | 1.719 | 2005 | |
| 45 | Paul Kemp | 1.739 | 2000 | |
| 46 | Mark Gregg | 1.744 | 2009 | |
| 47 | José Maes | 1.747 | 1996 | |
| 48 | Bennett Owens | 1.749 | 1979 | |
| 49 | Gerald Erickson# | 1.752 | 2007 | |
| 50 | Paul Martin | 1.753 | 1978 | |
| 51 | Brent House# | 1.756 | 2008 | |
| 52 | Steve Morrison | 1.760 | 1995 | |
| 53 | Augusto Rúbio | 1.762 | 2011 | |
| 54 | Ángel Rodríguez | 1.764 | 1998 | |
| 55 | Daniel Best | 1.765 | 1992 | |
| 56 | Cordell Fullerton | 1.767 | 1994 | |
| 57 | Hideaki Hayagawa | 1.768 | 1968 | |
| 57 | Alberto Coronado | 1.768 | 1993 | |
| 59 | Víctor Flores | 1.771 | 1978 | |
| 60 | Randy Laidlaw | 1.773 | 1989 | |
| 61 | Mario Montoya | 1.774 | 2008 | |
| 61 | Esteban Aguirre | 1.774 | 2008 | |
| 63 | Jim Thompson | 1.775 | 1968 | |
| 64 | Sidney Goodwin | 1.776 | 1979 | |
| 65 | Alberto Cortéz | 1.779 | 2000 | |
| 66 | Arnold Dittmar | 1.786 | 1960 | |
| 67 | Oliver Hernández | 1.791 | 1996 | |
| 68 | Salvador Uribe# | 1.796 | 2013 | |
| 69 | José Rodríguez | 1.797 | 1995 | |
| 69 | Donato Gil | 1.797 | 1995 | |
| 69 | Masayoshi Tsuchiya# | 1.797 | 2011 | |
| 72 | Mike Hunter# | 1.800 | 2014 | |
| 73 | Raúl Guzmán | 1.803 | 1988 | |
| 74 | Robert Tedeschi | 1.810 | 1963 | |
| 75 | Ronnie Gordon# | 1.811 | 2010 | |
| 76 | António Miranda | 1.814 | 1997 | |
| 77 | Dan-zu Sen# | 1.817 | 2002 | |
| 78 | Manuel Ortíz | 1.821 | 1985 | |
| 79 | Troy Larson | 1.824 | 2001 | |
| 79 | Ricardo Velásquez | 1.824 | 1979 | |
| 81 | Bill Mitchell | 1.828 | 1969 | |
| 82 | Dan Church | 1.829 | 1979 | |
| 83 | Mark Fulton | 1.831 | 1993 | |
| 84 | Kelly Pierce | 1.833 | 1995 | |
| 84 | Jack Mueller | 1.833 | 1989 | |
| 86 | Marcus Allen | 1.838 | 1964 | |
| 87 | Tim Bane | 1.840 | 1989 | |
| 88 | Sam Torres | 1.842 | 1996 | |
| 89 | Lowell MacDonald | 1.845 | 1992 | |
| 90 | Luis Rivera# | 1.849 | 2013 | |
| 91 | Don Parkinson | 1.851 | 1990 | |
| 92 | Sean Connolly | 1.854 | 1993 | |
| 92 | Dan Dillard | 1.854 | 1994 | |
| 94 | Estaçio Cepa | 1.855 | 1998 | |
| 95 | Manny Ramírez | 1.857 | 1998 | |
| 96 | Lowell MacDonald | 1.860 | 1993 | |
| 97 | James Ayers | 1.861 | 1962 | |
| 98 | Kade Brady | 1.862 | 2010 | |
| 99 | Joaquín Elizondo | 1.864 | 2003 | |
| 100 | Weston Curtis | 1.870 | 1968 |
