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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Mel Holmes | 401 | 1980-1996 | |
| 2 | Ramón López | 365 | 1980-1991 | |
| 3 | Ron Allen | 338 | 1990-2006 | |
| 4 | Domingo Hernández | 329 | 1966-1977 | |
| 5 | Merrill Humphrey | 323 | 1969-1983 | |
| 6 | Robert Archer | 316 | 1992-2006 | |
| 6 | Tom Schaefer* | 316 | 1972-1989 | |
| 8 | Randy McKay* | 315 | 1975-1992 | |
| 9 | Bill Jackson | 308 | 1964-1978 | |
| 10 | Wilson Gonzáles* | 302 | 1978-2000 | |
| 11 | Arturo Vega | 299 | 1982-1998 | |
| 12 | Robert Chacón# | 284 | 2000-2015 | |
| 13 | Mike Williamson | 276 | 1981-1999 | |
| 14 | Jason Richardson | 273 | 1986-2001 | |
| 15 | José Vásquez# | 269 | 2001-2015 | |
| 16 | Hayden Reese# | 268 | 2001-2015 | |
| 17 | Steven Pippy | 266 | 1990-1998 | |
| 18 | Neil Guillén# | 265 | 2003-2015 | |
| 19 | Jeffrey Adams | 247 | 1956-1971 | |
| 20 | Eduardo Vega# | 243 | 2002-2015 | |
| 21 | Carl Smith | 237 | 1963-1979 | |
| 21 | Peter Sánchez | 237 | 1996-2013 | |
| 23 | Chris Anderson* | 225 | 1974-1986 | |
| 23 | Joe Dunn | 225 | 1964-1976 | |
| 23 | Marcos Garza# | 225 | 2005-2015 | |
| 26 | Don Smith | 220 | 1971-1986 | |
| 27 | Joe Prince | 217 | 1963-1980 | |
| 27 | Tomás Reyes | 217 | 1969-1982 | |
| 29 | Paul Belcher | 208 | 1992-2008 | |
| 30 | Júlio Canales | 206 | 2002-2013 | |
| 31 | Jesús Delvalle | 203 | 1968-1980 | |
| 32 | Roger Grant | 202 | 1957-1968 | |
| 33 | David Wallace | 194 | 1996-2008 | |
| 34 | Guy Sánchez | 191 | 1994-2008 | |
| 34 | Alberto Árias | 191 | 1998-2008 | |
| 36 | Luis Soto | 190 | 1997-2008 | |
| 37 | Tommy James | 189 | 1987-1999 | |
| 38 | Sergio Guzmán | 188 | 1982-1993 | |
| 38 | Kevin Lyons# | 188 | 2008-2015 | |
| 38 | Ramón López | 188 | 1968-1982 | |
| 41 | Carl Garrett | 179 | 1975-1990 | |
| 41 | John Krum | 179 | 1956-1974 | |
| 43 | Christopher Jones | 166 | 1953-1972 | |
| 44 | Santiago Camacho# | 164 | 2003-2015 | |
| 44 | Francisco Rey | 164 | 1970-1981 | |
| 46 | Jesús Ortíz | 162 | 1963-1976 | |
| 47 | Alberto Rodríguez | 157 | 1999-2013 | |
| 48 | Tim Johnson | 155 | 1986-1997 | |
| 49 | Diego Hernández# | 150 | 2008-2015 | |
| 49 | Zach Thornton | 150 | 1974-1985 | |
| 51 | José Quiñones | 149 | 1995-2006 | |
| 52 | António González* | 146 | 1979-1994 | |
| 53 | Mark McEachan | 144 | 1972-1986 | |
| 54 | Charlie Adkins | 143 | 1993-2007 | |
| 54 | Keith Lossett | 143 | 1957-1967 | |
| 56 | Iván Franco | 140 | 1992-1999 | |
| 57 | Milan Alarcon | 137 | 1959-1972 | |
| 58 | Carlos García | 136 | 1974-1984 | |
| 59 | Kenny Arrington# | 134 | 2006-2015 | |
| 60 | Israel González# | 133 | 2004-2015 | |
| 61 | Cliff Cameron | 132 | 1962-1973 | |
| 62 | Darren Kelly | 129 | 1963-1977 | |
| 63 | Italo Romanelli | 128 | 2000-2010 | |
| 63 | Norman Williams Jr. | 128 | 1983-1988 | |
| 65 | Bob Simon | 125 | 1979-1992 | |
| 66 | Stanford Reyes# | 124 | 2002-2015 | |
| 67 | Esteban Hernández | 120 | 1962-1976 | |
| 68 | Jose Castillo | 118 | 1955-1969 | |
| 68 | Jeramy Henderson* | 118 | 1952-1964 | |
| 70 | B.J. Boone | 116 | 1985-2000 | |
| 71 | Keith Meidinger | 115 | 1953-1969 | |
| 72 | Alfredo Barrios | 114 | 1995-2002 | |
| 72 | Mario Cabanillas | 114 | 2002-2010 | |
| 72 | Neil Hensley | 114 | 1977-1985 | |
| 75 | Von Anderson | 111 | 1990-2003 | |
| 75 | Ty Combs | 111 | 1964-1971 | |
| 75 | Henry Peterson | 111 | 1956-1966 | |
| 75 | Jeffery Wells | 111 | 1967-1980 | |
| 79 | Gerald Goggin | 110 | 1957-1968 | |
| 79 | Rob Knight# | 110 | 2004-2015 | |
| 81 | Francisco López# | 108 | 2007-2014 | |
| 82 | Jaime Nieves | 107 | 1994-2002 | |
| 82 | Paul O'Neill* | 107 | 1952-1962 | |
| 84 | Luis García | 106 | 1966-1976 | |
| 84 | Lonnie Morgan | 106 | 1986-2002 | |
| 84 | Mark Sweeney# | 106 | 2004-2015 | |
| 87 | Rob Scott | 101 | 1979-1989 | |
| 88 | George Powell | 99 | 1960-1968 | |
| 89 | Jeremías Rojas | 98 | 1982-1996 | |
| 90 | Keith Dixon | 96 | 1982-1988 | |
| 90 | Ernesto Silva | 96 | 2004-2007 | |
| 90 | Juan Vazquez | 96 | 1956-1964 | |
| 93 | Rubén Alemán | 94 | 1998-2013 | |
| 93 | Pat Townsend | 94 | 1988-2001 | |
| 95 | Roberto Bexiga | 93 | 1988-1995 | |
| 95 | Keith Riggle | 93 | 1968-1986 | |
| 97 | Fred Aplin# | 92 | 2003-2015 | |
| 97 | Tyler Daniels* | 92 | 1977-1994 | |
| 99 | Juan Vázquez | 89 | 1983-1992 | |
| 100 | Michael Dade | 88 | 1960-1975 |
